Fatal Aplastic Anaemia after Chloramphenicol

Fatal aplastic anaemia following sulphaphenazole (Orisulf) therapy.

LEGGATT, P. 0. and WALTON, E. W. (1956): Wegener's Granulomatosis, Thorax, II, 94. MooRE, P. M., BEARD, E. E., THOBURN, T. W., and WILLIAMs, H. L. (I951): Idiopathic (lethal) Granuloma of Mid-line Facial Tissues Treated with Cortisone Report of a Case, Laryngoscope (St. Louis), 6i, 320. WALTON, E. W. (1958): Giant Cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis), Brit. med. 7....

Fatal aplastic anemia following apparent "dose-related" chloramphenicol toxicity.

T H E R E C O o N I T ! O N of ampicillin-resistant Hemophilus influenzae ~ has increased the use of chloramphenicol, particularly in management of invasive infections caused by this bacterium. Bone marrow toxicity, however, is a serious hazard. Based primarily on clinical data, two different bone marrow toxicities have been proposed. Reversible bone marrow suppression is frequent and dose rela...

Aplastic Anaemia.

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...

Aplastic Anaemia in Children.

A anaemia is a life threatening blood disorder that affects a large number of children each year in India. Exposure to toxic agents like benzene, radiation and viruses like hepatitis A have been implicated in its aetiology. The incidence in developing countries is far higher compared to developed countries. Investigating a child with pancytopenia is more complex than that of an adult as numerou...